Human BD-2 recombinant Protein
hBD-2, Defensin beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4, DEFB102, DEFB2, DEFB4P.
Description of Human BD-2
Recombinant Human Beta defensin-2 (BD-2) is a 41 amino acid peptide, with a molecular mass of 4,3 kDa. All Defensins are highly similar in their protein sequence. They are microbicidal and cytotoxic peptides made by neutrophils. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified: BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. Human BD-1 and Human BD-2 are monomeric, while Human BD-3 is a dimer. Defensins can act as chemoattractants towards immature dendritic cells and memory T-cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, they are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.
The ED50 of 10-100ng/ml was determined by the ability to chemoattract immature human dendritic cells.
We recommend a quick spin followed by reconstitution in water to a concentration of at least 100 µg/ml, which can then be further diluted. Do not vortex. This solution can be stored at 2-8°C for up to 1 week or in working aliquots at -20°C to -80°C. Working aliquots should be at the highest practical concentration.
The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18°C. Reconstituted BD-2 should be stored in working aliquots at -20°C to -80°C. Please avoid repeated freeze-thaw cycles.
Amino Acid Sequence
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Shipped at room temperature
To buy Human BD-2 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human BD-2 is an alternative for the no longer available Promokine BD-2, human, recombinant (C-65250).
All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Paying by bank transfer
We ship with UPS
Free shipping for orders above 500 € within Germany