Human BD-2 recombinant Protein

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+49 (0) 40 . 43 20 84 48 0

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: hBD-2, Defensin beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4, DEFB102, DEFB2, DEFB4P.

Source: E. coli

Biological activity: ≥ 2 x 106 units/mg

Purity: ≥ 98 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1182.950.005 5 g 90 €
1182.950.020 20 g 175 €
1182.950.199 1 mg on request

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

hBD-2, Defensin beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4, DEFB102, DEFB2, DEFB4P.

 

Description of Human BD-2

Recombinant Human Beta defensin-2 (BD-2) is a 41 amino acid peptide, with a molecular mass of 4,3 kDa. All Defensins are highly similar in their protein sequence. They are microbicidal and cytotoxic peptides made by neutrophils. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified: BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. Human BD-1 and Human BD-2 are monomeric, while Human BD-3 is a dimer. Defensins can act as chemoattractants towards immature dendritic cells and memory T-cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors, they are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.

 

Biological Activity

The ED50 of 10-100ng/ml was determined by the ability to chemoattract immature human dendritic cells.

 

Reconstitution

We recommend a quick spin followed by reconstitution in water to a concentration of at least 100 g/ml, which can then be further diluted. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest practical concentration.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted BD-2 should be stored in working aliquots at -20C to -80C. Please avoid repeated freeze-thaw cycles.

 

Lupe Zoom

Amino Acid Sequence

GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

 

Shipping symbol Shipped at room temperature

 

 

 

 

 

 

 

 

To buy Human BD-2 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human BD-2 is an alternative for the no longer available Promokine BD-2, human, recombinant (C-65250).

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500 € within Germany

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