Human Butyrylcholinesterase (BChE)

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	Proteins Synonyms: BChE, Acylcholine acylhydrolase, Pseudocholinesterase, BuChase, Plasma Cholinesterase, Choline esterase II, CHE1, CHE2, E1 Biological Activity: ≥ 50 U/mg protein Source: Human Plasma Purity: ≥ 90% by SDS-PAGE Physical State: Lyophilized from 100 mM L-Histidine, 240 mM sucrose, 0.3 mM TWEEN 20, pH 6.0. Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-020305-10UNITS 10 units 135 € 16-16-020305-100UNITS 100 units 690 € 16-16-020305-1000UNITS 1000 units 2.725 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

BChE, Acylcholine acylhydrolase, Pseudocholinesterase, BuChase, Plasma Cholinesterase, Choline esterase II, CHE1, CHE2, E1

 

Description of Human Butyrylcholinesterase (BChE)

Human Butyrylcholinesterase (BChE) is a 340 kDa protein. Butyrylcholinesterase (BChE), a tetrameric glycoprotein within the serine hydrolase family, exhibits broad substrate specificity beyond its canonical role in hydrolyzing acetylcholine. Its enzymatic repertoire includes aryl acylamidase activity, protease enhancement, and detoxification of neuromuscular blockers like succinylcholine. Genetic polymorphisms in the BCHE gene produce variants with altered activity, including silent forms linked to prolonged apnea during anesthesia. While once considered functionally redundant, BChE is now recognized for critical roles in neurodevelopment, lipid metabolism, and modulating aggression via ghrelin hydrolysis. Pathologically, BChE accumulates in Alzheimer’s disease plaques and tangles, with altered isoform ratios correlating with disease progression. Clinically, BChE deficiency causes pseudocholinesterase deficiency, impairing metabolism of anesthetics and organophosphorus (OP) agents. Its bioscavenging capacity underpins therapeutic applications: such as the detoxification of cocaine and OP nerve agents. Emerging evidence implicates BChE in metabolic syndrome, with activity inversely correlating with obesity and cardiovascular risk, and SIDS.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Biological Activity

≥ 50 U/mg protein. One unit will hydrolyze one micromole of butyrylcholine to choline and butyrate per minute at pH 8.0 at 37oC

 

Storage

For long term, store Human Butyrylcholinesterase (BChE) at -20°C.

 

Applications

Enxymatic Assays, Protein Chemistry Studies, Nerve agents, Toxin research.

 

Citations/Publications

NCBI: https://www.ncbi.nlm.nih.gov/protein/P06276

 

Shipped with ice packs

 

Gel Scan of Human Butyrylcholinesterase (BChE)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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