Human FGF-23 recombinant Protein

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Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: Tumor-derived hypophosphatemia-inducing factor, HYPF, ADHR, HPDR2, PHPTC

Source: E. coli

Biological activity: see below

Purity: ≥ 95 % (SDS-PAGE)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1394.950.005 5 g 60 €
1394.950.020 20 g 159 €
1394.950.199 1 mg 2.990 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

Tumor-derived hypophosphatemia-inducing factor, HYPF, ADHR, HPDR2, PHPTC

 

Description of Human FGF-23

Recombinant Human Fibroblast Growth Factor-23 (FGF-23) is a 228 amino acid protein, with a molecular mass of 22,5 kDa. It is a heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family. FGF family members possess extensive mitogenic and cell survival functions, and are involved in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Together with FGF-21 and FGF-19 it constitutes an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein (vergl.1628.954.xyz) as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1.

 

Biological Activity

The ED50 of ≤ 0.05-0.5 g/ml was determined by the dose-dependent proliferation of NIH/3T3 in the presence of recombinant murine Klotho (5g/ml) and heparin (10g/ml).

 

Reconstitution

We recommend a quick spin followed by reconstitution in water to a concentration of at least 100 g/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week or in working aliquots at -20C to -80C. Working aliquots should be at the highest practical concentration. For long term storage we recommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA.

 

Stability

The lyophilized protein is stable at room temperature for up to 1 month and at least until the lot specific expiry date if kept below -18C. Reconstituted FGF-23 should be stored in working aliquots at -20C to -80C if possible with carrier protein. Please avoid repeated freeze thaw cycles.

 

Amino Acid Sequence

MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

 

To buy Human FGF-23 please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

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