Human Flt-4/Fc Chimera, sVEGFR-3 (InCs) recombinant Protein
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soluble vascular endothelial growth factor receptor-3, FLT4, PCL, LMPH1A, fms-related tyrosine kinase 4
Description of Human Flt-4/Fc Chimera, sVEGFR-3 (InCs)
Recombinant human soluble Vascular Endothelial Growth Factor Receptor-3 (sVEGFR-3) was fused with the Fc part of human IgG1. The recombinant mature sVEGFR-3/Fc is a disulfide-linked homodimeric protein. The sVEGFR-3/Fc monomers have a mass of approximately 130 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774). All three VEGF receptors belong to the class III subfamily of receptor tyrosine kinases (RTKs) characterised by the seven immunoglobulin-like loops in the extracellular domain. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. They play key roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The VEGFR-3/FLT-4 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 23aa residue signal peptide. Mature VEGFR-3/FLT-4 is composed of a 751aa residue extracellular domain, a 22aa transmembrane domain and a 482aa residue cytoplasmic domain. Both VEGF family members VEGF-C and VEGF-D have been shown to bind and activate VEGFR-3/FLT-4. The FLT-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial at latter stages of development. It is important for lymphangiogenesis.
Measured by its ability to bind recombinant rat VEGF-C in a functional solid phase binding assay. Immobilised recombinant human sVEGFR-3/Fc at 5µg/ml can bind recombinant rat VEGF-C in a linear range of 8-500ng/ml.
The lyophilized sVEGFR-3/Fc is soluble in water and most aqueous buffers and should be reconstituted in PBS or medium to a concentration not lower than 100µg/ml.
Amino Acid Sequence
YSMTPPTLNI TEDSYVIDTG DSLSISCRGQ HPLEWTWPGA QEVLTTGGKD SEDTRVVHDC EGTEARPYCK VLLLAQTHAN NTGSYHCYYK YIKARIEGTT AASTYVFVRD FKHPFINKPD TLLVNRKDSM WVPCLVSIPG LNITLRSQSS ALHPDGQEVL WDDRRGMRVP TQLLRDALYL QCETTWGDQN FLSNLFVVHI TGNELYDIQL YPKKSMELLV GEKLVLNCTV WAEFDSGVTF DWDYPGKQAE RAKWVPERRS QQTHTELSSI LTIHNVSQND LGPYVCEANN GIQRFRESTE VIVHEKPFIS VEWLKGPVLE ATAGDELVKL PVKLAAYPPP EFQWYKDRKA VTGRHNPHAL VLKEVTEASA GVYTLALWNS AAGLRQNISL ELVVNVPPHI HEKEASSPSI YSRHSRQTLT CTAYGVPQPL SVQWHWRPWT PCKTFAQRSL RRRQQRDGMP QCRDWKEVTT QDAVNPIESL DSWTEFVEGK NKTVSKLVIQ DANVSAMYKC VVVNKVGQDE RLIYFYVTTI PDGFSIESEP SEDPLEGQSV RLSCRADNYT YEHLRWYRLN LSTLHDAQGN PLLLDCKNVH LFATPLEANL EEAEPGARHA TLSLNIPRVA PEDEGDYVCE VQDRRSQDKH CHKKYLSVQA LEAPRLTQNL TDLLVNVSDS LEMRCPVAGA HVPSIVWYKD ERLLEKESGI DLADSNQRLS IQRVREEDAG RYLCSVCNAK GCVNSSASVA VEGSEDKGSM ESDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPML DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
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