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Human IFN-beta 1a (glycosylated, HSA) recombinant Protein
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Protein Synonyms: Leukocyte interferon, B cell interferon, Type I interferon, Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1a, MGC96956. Source: CHO Biological activity: ≥ 2.0 x 108 IU/mg Purity: ≥ 99 % (SDS-PAGE, RP-HPLC) Manufacturer: |
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Active Bioscience
Product Details
Synonyms
Leukocyte interferon, B cell interferon, Type I interferon, Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1a, MGC96956.
Description of Human IFN-beta 1a (glycosylated, HSA)
Recombinant human Interferon-beta 1a (IFN-beta 1a) derived from CHO is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-beta 1a has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry. Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN- alpha is an acid stable molecule that signals through IFN-alpha/-betaR, which is also used by IFN-beta. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-alpha contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity.
Biological Activity
The biological activity of human IFN-beta was based on analysis using the WISH cell line with VSV as the challenge virus. The specific activity was determined to be ≥ 2.0 x 108 IU/mg.
Reconstitution
We recommend a quick spin followed by reconstitution in sterile water to a concentration of at least 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability
The lyophilized protein is stable until the indicated expiry date if stored ≤ -20°C. Reconstituted IFN-beta 1a is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. For long term storage we rec-ommend to add at least 0.1% HSA (order number: 2835.955.xyz or 2835.958.xyz) or BSA (order number: 2835.919.xyz). Please avoid repeated freeze-thaw cycles.
Shipped at room temperature
To buy Human IFN-beta 1a (glycosylated, HSA) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human IFN-beta 1a (glycosylated, HSA) is an alternative for the no longer available Promokine IFN-beta 1a, human, recombinant (CHO) (C-60591).
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Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
