Human IL-1 alpha recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha, IL1, IL-1A, IL1F1.

Source: E. coli

Biological activity: ≥ 1.0 x 109 IU/mg

Purity: ≥ 97 % (SDS-PAGE, RP-HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1495.950.002 2 µg 90 €
1495.950.010 10 µg 175 €
1495.950.199 1 mg 3.150 €

Please inquire for other vial sizes and custom vialing.



Product Details


Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha, IL1, IL-1A, IL1F1.


Description of Human IL-1 alpha

Recombinant human Interleukin-1 alpha (IL-1 alpha) is a 18.0 kDa protein containing 159 amino acid residues. IL-1 alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macro-phages, keratinocytes and other epithelial cells. Both IL-alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymo-cyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.


Biological Activity

The ED50 of ≤ 0.001ng/ml was determined by the dose-dependent stimulation of the proliferation of murine D10S cells. It corresponds to a specific activity of ≥ 1.0 x 109 units/mg.



We recommend a quick spin followed by reconstitution in water to a concentration of 0.1 - 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20°C for future use.



The lyophilized protein is stable at room temperature for a few weeks, but best stored at -20°C. Reconstituted rhIL-1alpha should be stored in working aliquots at -20°C. Please avoid repeated freeze thaw cycles.


Lupe Zoom

Amino Acid Sequence



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To buy Human IL-1 alpha please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human IL-1 alpha is an alternative for the no longer available Promokine IL-1 alpha, human, recombinant (E. coli) (C-61112).


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Errors, changes and availability excepted.




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