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Human Immunoglobulin G, Fab'2 Fragment (IgG Fab'2)
IgG Fab'2 Fragment generated from multiple donor native IgG Polyclonal, whole molecule
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Proteins Synonyms: IgG Fab'2 Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Single arc by IEP against antisera to whole human serum. Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgG Fab'2
Description of Human Immunoglobulin G, Fab'2 Fragment (IgG Fab'2)
Human Immunoglobulin G, Fab'2 Fragment (IgG Fab'2) is a 110 kDa protein. The IgG F(ab')₂ fragment is a bivalent, proteolytic product of Immunoglobulin G, retaining two antigen-binding (Fab') regions connected by disulfide bonds in the hinge region while excluding the Fc domain2. This structural configuration preserves avidity through dual antigen engagement, offering a higher association constant compared to monovalent Fab fragments-particularly advantageous for low-affinity antibodies requiring enhanced binding stability. The absence of the Fc region eliminates interactions with Fc receptors and complement proteins, minimizing nonspecific immune activation and background noise in diagnostic assays3. Therapeutically, F(ab')₂ fragments are pivotal in antivenom formulations where rapid toxin neutralization without Fc-mediated inflammation reduces adverse reactions and mitigates late coagulopathy in rattlesnake envenomation. In oncology, their smaller size enhances tumor penetration, while faster blood clearance improves imaging signal-to-noise ratios in radiolabeled diagnostics Immunologically, Diagnostically, F(ab')₂ fragments enable precise antigen detection in flow cytometry and immunohistochemistry by avoiding Fc receptor cross-reactivity. Their divalent binding also stabilizes antigen-antibody complexes in immunoassays, ensuring high specificity for low-abundance targets. Emerging applications include autoimmune disease management, where F(ab')₂ fragments neutralize autoantibodies while circumventing complement activation. By combining targeted avidity with reduced immunogenicity, IgG F(ab')₂ fragments bridge therapeutic efficacy and diagnostic precision across diverse clinical contexts.
Source
Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin G, Fab'2 Fragment (IgG Fab'2) at -20°C.
Applications
Biotherapeutics, Flow Cytometry, Immunohistochemistry, Antisera Production, In Vitro Diagnostic.
Shipped with dry ice
Gel Scan of Human Immunoglobulin G, Fab'2 Fragment (IgG Fab'2)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
