Human Immunoglobulin G, Light Chain

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	Proteins Synonyms: IgG LC Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-LC-1MG 1 mg 175 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG LC

 

Description of Human Immunoglobulin G, Light Chain

The IgG light chain, comprising either kappa (κ) or lambda (λ) subtypes, is a 25 kDa polypeptide critical for antigen recognition and antibody diversity. Each light chain pairs with a heavy chain via disulfide bonds, forming the variable (VL) and constant (CL) domains that confer antigen-binding specificity and structural stability. In humans, κ and λ light chains maintain a serum ratio of ~2:1 for intact IgG, while free light chains (FLCs) exhibit a 1:1.5 ratio. Deviations from these ratios, particularly κ/λ FLC ratios <0.26 or >1.65, signal monoclonal proliferation in conditions like multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS). Pathologically, misfolded IgG light chains drive AL amyloidosis, forming insoluble fibrils in organs such as the heart and kidneys, while non-fibrillar deposits in light chain deposition disease (LCDD) cause renal failure and hepatic dysfunction. Bence Jones proteins, urinary FLCs detected in 66% of myeloma cases, reflect clonal plasma cell activity. Elevated polyclonal FLCs also contribute to inflammatory diseases by activating mast cells and neutrophils. Clinically, serum FLC assays supersede urine tests for sensitivity in diagnosing oligosecretory myeloma and monitoring treatment response. Immunohistochemistry leveraging light chain restriction (κ or λ predominance) aids in differentiating reactive lymphoproliferations from B-cell lymphomas.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G, Light Chain at ≤ -20°C.

 

Applications

Antisera Production, Cancer, Inflammation, In Vitro Diagnostic.

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G, Light Chain

Fig. 1: SDS-PAGE Gel

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

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