Human Immunoglobulin G1 (IgG1)

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: IgG Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090707-1-100UG 100 µg 55 € 16-16-090707-1-1MG 1 mg 290 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgG

 

Description of Human Immunoglobulin G1 (IgG1)

Human Immunoglobulin G1 (IgG1) is a 146 kDa protein. Serum IgG1 constitutes approximately 65% of total immunoglobulin G, making it the predominant subclass in human circulation. This glycoprotein features a 15-amino-acid hinge region that confers intermediate flexibility between IgG subclasses, enabling broad antigen recognition and effector functions. The Fc domain of IgG1 binds high-affinity FcγRI (CD64) via a hydrophobic pocket accommodating Leu235, facilitating immune complex clearance through phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and complement activation. IgG1’s Fc also interacts with FcγRIII and C1q, making it central to both innate and adaptive immunity. Abnormally elevated IgG1 levels are hallmark in multiple myeloma, where clonal plasma cell proliferation disrupts normal immunoglobulin ratios, often leading to renal complications. Conversely, IgG1 deficiency (<4.9 g/L) predisposes individuals to recurrent bacterial infections due to impaired opsonization of protein antigens like tetanus toxoid7. Autoimmune disorders such as systemic lupus erythematosus (SLE) and Sjögren’s syndrome exhibit IgG1-predominant autoantibodies targeting nuclear antigens, which exacerbate tissue damage via FcγR-mediated neutrophil and macrophage activation. IgG1 also drives type II hypersensitivity reactions, with FcγRIII cross-linking on mast cells contributing to anaphylactic pathways.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin G1 (IgG1) at ≤ -80°C.

 

Applications

ELISA, In Vitro Diagnostic, Glycoproteomics, Biotherapeutics, Inflammation, Infection, Flow Cytometry, Autoimmune Disease, Cancer.

 

Citations/Publications

Zhang, W., et al., (2024), 'Fc–Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies', Journal for ImmunoTherapy of Cancer 12: e009034. Available at: doi:10.1136/jitc-2024-009034 
Devaux, J. J., et al., (2016), 'Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy', Neurology, 86(9): pp 800-7. Available at: doi: 10.1212/WNL.0000000000002418.
Jordakieva, G., et al., (2021), 'IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer', ONCOIMMUNOLOGY, 10(1): pp e1880687. Available at: https://doi.org/10.1080/2162402X.2021.1880687
Ermet, D., et al., (2019), 'The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.', Front. Immunol. 10:1230. Available at: doi: 10.3389/fimmu.2019.01230 
Kammeijer, G. S. M., et al., (2016), 'Dopant Enriched Nitrogen Gas Combined with Sheathless Capillary Electrophoresis−Electrospray Ionization-Mass Spectrometry for Improved Sensitivity and Repeatability in Glycopeptide Analysis', Anal. Chem. 88: 5849−5856. Available at: DOI: 10.1021/acs.analchem.6b00479

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin G1 (IgG1)

Fig. 1: SDS-PAGE Gel

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Immunoglobulin G1 (IgG1) please click on the Shopping List Symbol right from the indicated price. This will add Human Immunoglobulin G1 (IgG1) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.