Human Immunoglobulin M (IgM)

1. Home
2. Proteins
3. Human Proteins

Product Overview, Sizes and Prices
	Proteins Synonyms: IgM Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3 Manufacturer:  Athens Research & Technology	Article No. Size Price   16-16-090713-1MG 1 mg 160 € 16-16-090713-10MG 10 mg 1.100 € Please inquire for other vial sizes and custom vialing.

 

 

Produktdetails

Synonyms

IgM

 

Description of Human Immunoglobulin M (IgM)

Human Immunoglobulin M (IgM) is a 950 kDa protein. Serum IgM is a pentameric or hexameric macro-immunoglobulin that serves as the first-line defense in humoral immunity. Constituting 1.2–4.0 mg/mL in plasma, it features 10–12 antigen-binding sites, enabling high-avidity interactions with pathogens, particularly non-protein antigens like microbial carbohydrates and lipids. As the earliest antibody produced during infection and the primary immunoglobulin in neonates, IgM activates the classical complement pathway through C1 binding, promoting opsonization and pathogen lysis. Its inability to cross the placenta makes elevated neonatal IgM a marker for intrauterine infections. IgM plays dual roles in autoimmune pathology. While natural IgM aids homeostasis by clearing cellular debris, autoreactive IgM drives diseases like cold agglutinin disease and idiopathic thrombocytopenic purpura through erythrocyte or platelet targeting4. Deficiencies manifest in Wiskott-Aldrich syndrome (linked to thrombocytopenia and recurrent infections) and Hyper IgM syndromes, characterized by impaired class-switching and susceptibility to Pneumocystis pneumonia, cryptosporidiosis, and malignancies. Clinically, IgM serves diagnostic and therapeutic purposes. It indicates recent infections through serological testing and helps identify autoimmune conditions via autoantibody detection. Intravenous immunoglobulin (IVIG) preparations containing IgM are used for immune thrombocytopenic purpura and Guillain-Barré syndrome, leveraging IgM’s immunomodulatory properties.

 

Source

Human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests

 

Storage

For long term, store Human Immunoglobulin M (IgM) at ≤ -80°C.

 

Applications

Complement System, In Vitro Diagnostics, Infection, Glycoproteomics, Biotherapeutics, Anaphylaxis, Rheumatoid Arthritis, Autoimmune Diseases, Wiskott-Aldrich syndrome.

 

Citations/Publications

Zhang, P., et al., (2020), 'Plasmonic scattering imaging of single proteins and binding kinetics', Nature Methods. 17: pp 1010–1017. Available at: https://doi.org/10.1038/s41592-020-0947-0
Khandelwal, S., et al., (2017), 'In Vitro Complement Activation By PF4/ Heparin Complexes Is Mediated By Plasma IgM', Blood 130: 3617. Available at: https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617
Khandelwal, S., et al., (2018), 'Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway, Blood. 132(23): 2431-2440. Available at: https://doi.org/10.1182/blood-2018-03-834598
Ma, G., et al., (2020), 'Optical imaging of single-protein size, charge, mobility, and binding', Nature Communications 11: pp 4768. Available at: https://doi.org/10.1038/s41467-020-18547-w
Zhang, P., et al., (2022), 'Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes', NATURE COMMUNICATIONS. 13: pp 2298. Available at: https://doi.org/10.1038/s41467-022-30046-8

 

Shipped with dry ice

 

Gel Scan of Human Immunoglobulin M (IgM)

Fig. 1: SDS-PAGE Gel

 

 

Download Datasheet

 

 

 

 

 

Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.

 

To buy Human Immunoglobulin M (IgM) please click on the Shopping List Symbol right from the indicated price. This will add Human Immunoglobulin M (IgM) to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

 

For business customers only. All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.