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Human Immunoglobulin M (IgM), mu chain
Native IgM mu chain. Processed from IgM from myeloma plasma
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Proteins Synonyms: IgM mu chain Source: Human Plasma Purity: ≥ 95% by SDS-PAGE Physical State: Lyophilized from 1.0 M acetic acid. Reconstitute with 1.0 M acetic acid to the pre-lyophilization volume. Dilutions must be made in Acetic Acid. Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
IgM mu chain
Description of Human Immunoglobulin M (IgM), mu chain
Human Immunoglobulin M (IgM), mu chain is a 75 kDa protein. The IgM heavy chain, known as the mu (µ) chain, is a fundamental component of IgM antibodies and consists of 576 amino acids. Each IgM molecule is composed of five mu chains, forming a pentameric structure that enables robust antigen binding and efficient activation of the complement system. The mu chain is distinguished by its high degree of evolutionary conservation across species, more so than the heavy chains of IgG or IgA, underscoring its essential role in the immune response. Purification of the mu chain is typically achieved by reducing the disulfide bonds that link it to the kappa and lambda light chains, allowing for detailed structural and functional studies. Clinically, abnormalities in the mu chain can be associated with immunodeficiency disorders, such as selective IgM deficiency, and certain B-cell malignancies like Waldenström’s macroglobulinemia. Additionally, the mu chain serves as a target in diagnostic assays for early infection and is a key marker in the study of B-cell development and immune system evolution.
Source
Human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests
Storage
For long term, store Human Immunoglobulin M (IgM), mu chain at ≤ -20°C.
Applications
Structural Studies, Antisera Production, Immunodeficiency, Waldenström’s macroglobulinemia.
Shipped with ice packs
Gel Scan of Human Immunoglobulin M (IgM), mu chain
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
