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Human Leucine-rich Alpha 2 Glycoprotein-1 (LRG1)
Native, whole molecule
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Proteins Synonyms: LRG1, LRG Source: Human Plasma Purity: ≥ 95% by SDS-PAGE. Positive reaction to anti-LRG1 on Western Blot. Physical State: Lyophilized from 20mM Tris, 20 mM NaCl, pH 7.5 Manufacturer: |
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Athens Research & Technology
Produktdetails
Synonyms
LRG1, LRG
Description of Human Leucine-rich Alpha 2 Glycoprotein-1 (LRG1)
Human Leucine-rich Alpha 2 Glycoprotein-1 (LRG1) is a 50 kDa protein. Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a multifunctional plasma protein present at concentrations of 21–50 µg/mL in healthy individuals. As an acute-phase protein, LRG1 levels rise significantly during bacterial infections and various inflammatory conditions, but its regulation is independent of traditional markers like C-reactive protein (CRP). LRG1 plays a key role in modulating immune and vascular responses, acting as an upstream regulator of the TGF-β signaling pathway and promoting angiogenesis by influencing endothelial cell behavior. It binds cytochrome c, a molecule involved in apoptosis, thereby potentially supporting cell survival during tissue injury and inflammation. Elevated LRG1 is recognized as a biomarker for multiple cancers-including non-small cell lung, colorectal, pancreatic, and ovarian cancer-where it correlates with disease progression and prognosis. Beyond oncology, LRG1 is implicated in cardiovascular, renal, autoimmune, and neurodegenerative diseases, such as Parkinson’s disease, and is being explored as a diagnostic and therapeutic target due to its roles in inflammation, vascular dysfunction, and tissue remodeling.
Source
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Storage
For long term, store Human Leucine-rich Alpha 2 Glycoprotein-1 (LRG1) at ≤ -20°C.
Applications
Infection, Inflammation, Cancer, Cardiovascular Disease, Autoimmune Diseases, Parkinson's, Biotherapeutics, In Vitro Diagnostics.
Citations/Publications
NCBI: https://www.ncbi.nlm.nih.gov/protein/P02750/
Shipped with ice packs
Gel Scan of Human Leucine-rich Alpha 2 Glycoprotein-1 (LRG1)
| Fig. 1: SDS-PAGE Gel |
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer
