EN
Human/Murine/Rat Activin A (InCs) recombinant Protein
Product Overview, Sizes and Prices |
||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Protein Synonyms: Inhba, Inhibin beta A, FSH releasing protein, Erythroid Differentiation Factor (EDF). Source: Insect cells Biological activity: ≥ 5 x 105 IU/mg Purity: ≥ 95 % (SDS-PAGE, HPLC) Physical state: Lyophilized Manufacturer: |
|
||||||||||||||||||||||||||||
Active Bioscience
Product Details
Synonyms
Inhba, Inhibin beta A, FSH releasing protein, Erythroid Differentiation Factor (EDF).
Description of Human/Murine/Rat Activin A (InCs)
Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues, belonging to the TGF-beta family. It exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin.
Biological Activity
The ED50 of ≤ 2ng/ml was determined by its ability to inhibit the proliferation of murine MPC-11 cells. It corresponds to a specific activity of ≥ 5.0 x 105 units/mg.
Reconstitution
We recommend a quick spin followed by reconstitution in water to a concentration of 50µg/ml. This will yield a solution of 10mM Citric Acid at pH 3.0 which can be stored 4°C for up tp 4 weeks or -20°C for future use. It can be diluted - preferably into PBS containing 2mg/ml albumin (e.g HSA ultra pure 2835.958.xyz) - and stored at -20°C or -80°C.
Stability
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted Activin A should be stored in working aliquots at -20°C. Please avoid repeated freeze-thaw cycles.
Amino Acid Sequence
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Shipped at room temperature
To buy Human/Murine/Rat Activin A (InCs) (W1100952002, W1100952010, W1100952050, W1100952100, W1100952199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« or the Shopping List Symbol in the top navigation to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable. Human/Murine/Rat Activin A (InCs) is an alternative for the no longer available Promokine Activin A, human, recombinant (InC) (C-60057).
All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Payment Methods
Paying by bank transfer
