Human PDGF-AB recombinant Protein

Please log in to see the special conditions of your institution.

 

Phone: +49 (0) 40 . 43 20 84 48 0

E-Mail: info@active-bioscience.de

 

Product Overview, Sizes and Prices

 

Protein

Synonyms: PDGFA, PDGF1, PDGF-A

Source: E. coli

Purity: ≥ 95 % (SDS-PAGE, silver stained)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1801.950.005 5 g 60 €
1801.950.010 10 g 150 €
1801.950.050 50 g 350 €
1801.950.100 100 g 590 €
1801.950.500 500 g 1.750 €
1801.950.199 1 mg 2.790 €

Please inquire for other vial sizes and custom vialing.

 

 

Product Details

Synonyms

PDGFA, PDGF1, PDGF-A

 

Description of Human PDGF-AB

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR- interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

 

Biological Activity

The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).

 

Reconstitution

Centrifuge vial prior to opening. The lyophilized PDGF-AB should be reconstituted in 50mM acetic acid to a concentration not lower than 100g/ml. For long term storage of reconstituted protein addition of carrier protein (e.g. BSA or HSA; 0.1%) is recommended.

 

Amino Acid Sequence

Alphachain :MSIEEAVPA VCKTRTVIYE IPRSQVDPTS ANFLIWPPCV EVKRCTGCCN TSSVKCQPSR VHHRSVKVAK VEYVRKKPKL KEVQVRLEEH LECACATTSL NPDYREEDTG RPRESGKKRK RKRLKPT Be tachain:MS LGSLTIAEPA MIAECKTRTE VFEISRRLID RTNANFLVWP PCVEVQRCSG CCNNRNVQCR PTQVQLRPVQ VRKIGIVRKK PIFKKATVTL GDHLACKCET VAAARPVT

 

 

 

To buy Human PDGF-AB please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button Shopping List & Order Form to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.

 

All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.

 

Errors, changes and availability excepted.

 

 

Payment Methods

Paying by bank transfer

Shipping

We ship with UPS

Free shipping for orders above 500  within Germany

This website uses cookies to store your Personal Shopping List. By using our website you accept the use of session cookies. Learn more
Got it