Human PDGF-AB recombinant Protein
Please log in to see the special conditions of your institution.
Phone: +49 (0) 40 . 43 20 84 48 0
PDGFA, PDGF1, PDGF-A
Description of Human PDGF-AB
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-ß. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-ß interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).
Centrifuge vial prior to opening. The lyophilized PDGF-AB should be reconstituted in 50mM acetic acid to a concentration not lower than 100µg/ml. For long term storage of reconstituted protein addition of carrier protein (e.g. BSA or HSA; 0.1%) is recommended.
Amino Acid Sequence
Alphachain :MSIEEAVPA VCKTRTVIYE IPRSQVDPTS ANFLIWPPCV EVKRCTGCCN TSSVKCQPSR VHHRSVKVAK VEYVRKKPKL KEVQVRLEEH LECACATTSL NPDYREEDTG RPRESGKKRK RKRLKPT Be tachain:MS LGSLTIAEPA MIAECKTRTE VFEISRRLID RTNANFLVWP PCVEVQRCSG CCNNRNVQCR PTQVQLRPVQ VRKIGIVRKK PIFKKATVTL GDHLACKCET VAAARPVT
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
To buy Human PDGF-AB (W1801950005, W1801950010, W1801950050, W1801950100, W1801950500, W1801950199) please click on the Shopping List Symbol right from the indicated price. This will add the product to your Shopping List. You can then click on the button »Shopping List & Order Form« to ask for a quote. We will send you your quote as soon as possible. Our offer will include institutional discounts where applicable.
All prices are net prices (excluding VAT). Final prices in our quote will contain VAT plus shipping costs if applicable. For further information please go to our Shipping page.
Errors, changes and availability excepted.
Paying by bank transfer
We ship with UPS
Free shipping for orders above 500 € within Germany