Human TGF-beta1 (glycosylated, HEK), cct-premium recombinant Protein

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Product Overview, Sizes and Prices



Synonyms: Transforming Growth Factor-1, Differentiation inhibiting factor, Cartilage-inducing factor.

Source: HEK

Biological activity: ≥ 2 x 107units/mg

Purity: ≥ 98 % (SDS-PAGE, HPLC)

Physical state: Lyophilized

Manufacturer:  Active Bioscience

Article No. Size Price  
1934.955.010 10 g 185 €
1934.955.050 50 g 590 €
1934.955.100 100 g 990 €
1934.955.500 500 g 2.990 €
1934.955.199 1 mg 4.900 €
1934.955.109 10 mg on request

Please inquire for other vial sizes and custom vialing.



Product Details


Transforming Growth Factor-1, Differentiation inhibiting factor, Cartilage-inducing factor.


Description of Human TGF-beta1 (glycosylated, HEK), cct-premium

Recombinant human Transforming Growth Factor-beta 1 (TGF-b1) is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. The three mammalian isoforms of TGF-beta, TGF-beta1,-beta2, -beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodelling and wound healing. They are secreted predominantly as latent complex which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors.


Biological Activity

The ED50 of ≤ 0.05 ng/ml was determined by TGF-beta 1s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. It corresponds to a specific activity of ≥ 2 x 107 units/mg.



We recommend a quick spin followed by reconstitution in sterile Citric Acid (10mM; pH 3.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20C to -80C.



The lyophilized protein is stable at room temperature for up to 1 month, at 4C for up to 6 months, and below -20C until expiry date. Reconstituted protein is stable for at least 12 months when stored in working aliquots with a carrier protein at -20C to -80C. Please avoid repeated freeze-thaw cycles.


Lupe Zoom

Amino Acid Sequence



Shipping symbol Shipped at room temperature









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