Human Relaxin-2 recombinant Protein

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Synonyms

Prorelaxin H2, RLN2, H2, RLXH2, H2-RLX.

Description of Human Relaxin-2

Recombinant human Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain. Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth.

Biological Activity

Data not available. Please also check 1997.950.xyz or 1997.952.xyz for use in cell culture.

Reconstitution

We recommend a quick spin followed by reconstitution in sterile filtered water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA, order number: 2835.955.xyz or 2835.958.xyz) and store in working aliquots at -20°C to -80°C.

Stability

The lyophilized protein is stable at room temperature for up 1 month and at 4°C up to 6 months. Working aliquots stored with a carrier protein are stable for at least 12 months at -20°C to -80°C. Please avoid repeated freeze-thaw cycles.

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Amino Acid Sequence

A-Chain: QLYSALANKC CHVGCTKRSL ARFC
B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
Interchain disulfid bonds: 35 <-> 172 und 47 <-> 185

Shipped at room temperature

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